When considering posthuman issues, scholars have mostly focused on contemporary technologies, works of art, or media phenomena. However, several traces of the great variety of posthuman issues can already be found in our cultural history. I wish to highlight some selected insights concerning the connection between blood and bliss that are of pressing relevance for some posthuman challenges. Thus, I wish to encourage scholars to investigate such issues further and to submit their reflections to the Journal of Posthuman Studies.In the Holy Mass the bread becomes the body of Christ, and the wine his blood. Jesus Christ is present during this ceremony, according to the Roman Catholic faith, and becomes one with us, the bearers of God’s image. Thus, our having been created in God’s image is reaffirmed, and we can hope for eternal life in the afterworld. The blood of Jesus Christ helps us to realize this afterlife. The Holy Mass reminds us of the Last Supper Jesus and his disciples had on the evening before his death. Three days after the crucifixion, God raised Jesus from death. Jesus was resurrected in a glorified body. Blood here has a redemptive power. “Christ’s blood is believed by Christians to cleanse the human soul of mortal sin.”1 Thus, it increases the chance of a blissful afterlife.“Ficino and his contemporaries went further, discussing youth and health as bodily substances which dwelt in the blood and that could be restored through the same liquid: ‘There is a power in human blood to both attract and, in turn, to follow human blood.’”2 Witches play a particularly interesting role when it comes to blood. Most Medieval theologians claimed that the devil was responsible for the work of the witches. “According to the Italian philosopher of the Renaissance, Marsilio Ficino, human blood naturally attracted human blood. The old women, called witches, were believed to drink the children’s blood to have their youth back; they were believed to go down the chimneys of the houses, especially on Thursday night, to suck out infants’ lives. Blood was, then, considered as a remedy for old age and decay as it is testified by a unique case of real vampirism. As in a gruesome fairy tale, during the late sixteenth century the Hungarian countess Elizabeth Bathory killed more than sixty young girls to drink their blood and reacquire her youth.”3 It might be interesting to note that the cultural origin of the witches can be traced to a night bird of prey from ancient mythology called the strix. The cultural connection between striges and witches can still be seen in the Italian term for a witch, which is strega. A blood-related practice of rejuvenation has already been mentioned in ancient Greek mythology, for example, in Book 7 of Ovid’s Metamorphoses: By replacing blood with an herbal juice cocktail and after erecting altars to Hecate, the goddess of magic, and Hebe, the goddess of youth, Medea helps Aeson, Jason’s father, to regain the strength of his youth.A further development of the cultural connection between blood and bliss can be found in vampire stories. The word “vampire” was first used in English in 1732. A vampire is “a deceased person.”4 “Vampires sucked the blood of the living, stopping their normal process of decay as corpses and confusing dangerously the boundaries between life and death.”5 Although accounts of vampires mostly come from eastern and southeastern Europe, during the late seventeenth century and the eighteenth century there was an active debate in Western Europe regarding the reality of the vampire. The belief in this kind of creature was, in fact, evidently in contradiction to the Christian doctrine of the resurrection. The uncorrupted “miraculous” body of the vampire was the negative reflection of that of the saint, while its bloodthirstiness could be interpreted as the inversion of Holy Communion, where Christians were materially absorbing the flesh and the blood of Jesus. The vampire constituted the disruption of a divine order according to which the soul should be freed from the corporeal reality and reach the otherworld, or, as in the case of the saints, be able to operate marvelously inside the body thanks to its holiness. According to the description of the eighteenth-century French Benedictine abbot Augustine Calmet, when vampires were taken out of the ground they “have appeared red, with their limbs supple and pliable, without worms or decay; but not without great stench, in contrast with the perfumes and oils issuing from the saints’ corpses.”6In Central and South America, vampire bats exist that can live solely on blood. Vampire bats were mentioned in the Bram Stoker novel from 1897 entitled Dracula, in which Dracula transforms himself into a bat several times. Dracula is deceased but behaves as if he were alive. The term undead is also being employed for human beings who have used cryonics. This description is different from that of related contemporary processes, but certain resonances are striking indeed. Cryopreservation may occur only once a human being is declared brain dead. Brain death does not have to be an irreversible state. It is conceivable that the molecules that are dissolved when brain death occurs can be repaired and reestablished by means of nanorobots, synthetic biology, and bioprinting. If this can be achieved, then the brain can become functional again and consciousness can be regained.This is the cultural background that needs to be considered when considering the biotechnological use of blood in our times. Even though the FDA has doubts concerning the idea of taking blood from the young so that old people can rejuvenate themselves, there is widespread interest in this technology.7 Reports exist that billionaires such as Peter Thiel have expressed an interest in this technology.8 However, when asked about this issue, Thiel explicitly stated that he was not a vampire.9 Whether or not this is the case, there seems to be some scientific evidence in favor of these kinds of technologies. On 31 May 2022, a news item announced that Chinese scientists had found a rejuvenation secret that allowed old mice to live longer on the basis of blood taken from younger mice.10In the Holy Mass, blood is being drunk to increase the chances of living a blissful afterlife. Witches, on the other hand, drink the blood of young people to regain their youth. This time a fulfilled life in this world is targeted. A further alternative is represented by vampires who are undead, and who drink blood to undo their own process of decay, so that they remain dead while behaving like someone who is alive. Contemporary technologies attempt to actually achieve what has been dealt with in magical stories of the past. In the case of cryonics, the goal is to reverse the state of being dead. This option is a new one and has not yet been presented in the examples of the Holy Mass, witches, or vampires. In the case of getting injections of a secret that was derived from the blood of young people, it can be stressed that this example is structurally analogous to what witches have done. Hence, it is not a vampire technology, but rather a witchcraft technology. As Chinese scientists have demonstrated recently, it seems to be a realistic goal. In contrast to the magical attempts of the past, technological innovations might actually enable us to realize the goals of which we dreamed so far only. This is an amazingly fascinating development. There seems to be at least a grain of truth in Arthur C. Clarke’s insight that “any sufficiently advanced technology is indistinguishable from magic.”11 Please feel free to submit further such intriguing historical issues to the Journal of Posthuman Studies.